Activation of the essential kinase pdk1 by phosphoinositide-driven trans-autophosphorylation

HIGHLIGHTS

• who: Aleksandra Levina from the Vienna Biocenter Medical University of British Columbia, Vancouver, BC V T , Canada have published the research: Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show that PDK1 activation by trans-autophosphorylation is dependent on a specific face-to-face dimer mediated by its u03b1G helix. The authors show that PDK1 exists in an autoinhibited conformation, irrespective of its phosphorylation state, which is directly activated by PIP3. The authors propose a model of lipiddependent PDK1 activation in which . . .
  

   

  

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