Activation of transcription factor creb in human macrophages by mycobacterium tuberculosis promotes bacterial survival, reduces nf-kb nuclear transit and limits phagolysosome fusion by reduced necroptotic signaling

HIGHLIGHTS

• who: Chrissy M. Leopold Wager and collaborators from the Editor:, University of Washington have published the article: Activation of transcription factor CREB in human macrophages by Mycobacterium tuberculosis promotes bacterial survival, reduces NF-kB nuclear transit and limits phagolysosome fusion by reduced necroptotic signaling, in the Journal: (JOURNAL) of March/31,/2023
• what: The authors show that CREB regulates bacterial trafficking by inhibiting phosphorylation of RIPK3 and MLKL proteins important in the necroptotic cell death pathway without influencing cell death. Altogether the authors demonstrate that CREB activation is key for immune evasion by M.tb . . .
  

   

  

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