HIGHLIGHTS
- who: Hironori Abe from the (UNIVERSITY) have published the paper: Active DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation, in the Journal: (JOURNAL) of 13/Oct/2022
- what: Because of the consistent effect of two independent ATR inhibitors, the authors focus on one of them, AZ20, in the experiments that follow. The authors have established a system to study MSCI ex vivo, and have performed in_vivo experiments in mice, to show that ATRmediated DDR signaling actively governs MSCI during meiotic prophase I and functions as the primary mechanism of chromosome regulation on . . .
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