Activin a directly impairs human cardiomyocyte contractile function indicating a potential role in heart failure development

HIGHLIGHTS

• who: Scott MacDonnell from the University of Colorado, United States have published the research work: Activin A directly impairs human cardiomyocyte contractile function indicating a potential role in heart failure development, in the Journal: (JOURNAL)
• what: The authors characterize the direct impact of Activin A on murine ventricular function, hiPSC-CMs, and human engineered cardiac tissues (HECTs). The authors propose a mechanism by which inflammatory signaling drives cardiac Activin A expression and contributes to CM dysfunction in patients with heart failure. The authors demonstrate that engagement of Activin A signaling is responsible for damping CM . . .
  

   

  

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