Acute axon damage and demyelination are mitigated by 4-aminopyridine (4-ap) therapy after experimental traumatic brain injury

HIGHLIGHTS

  • who: Kryslaine L. Radomski from the (UNIVERSITY) have published the Article: Acute axon damage and demyelination are mitigated by 4-aminopyridine (4-AP) therapy after experimental traumatic brain injury, in the Journal: (JOURNAL)
  • what: This study design demonstrates reproducible CC pathology and functional deficits to rigorously evaluate acute effects of 4-AP treatment. This analysis shows significant improvement, but not full restoration, of the complex molecular domains of nodal regions during the first week post-TBI with 4-AP treatment. This analysis showed that TBI significantly altered the strength-duration characteristics of the N2 CAP . . .

     

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