Adaptive single-kir+nkg2c+ nk cells expanded from select superdonors show potent missing-self reactivity and efficiently control hla-mismatched acute myeloid leukemia

HIGHLIGHTS

• who: Alvaro Haroun-u00adIzquierdo u200d u200d et al. from the leukemia) and BJAB (Burkitt-u00adlike Lymphoma) were reauthenticated using STR fingerprinting (ATCC) AML patient samples EDTA blood samples were collected at diagnosis from AML patients (Dep. of Hematology, Oslo University Hospital, Oslo, Norway). PBMC were isolated by Lymphoprep and cryopreserved in RPMI , with, % FBS and, % DMSO. Patients were genotyped by Illumina NGS platform (Dep. of Immunology, Oslo University Hospital, Oslo, Norway) and for this study, samples were selected from patients of either HLA-u00adC1/, or HLA-u00adC2/ , haplotypes. Flow cytometry-based NK cell functional assays NK cell . . .
  

   

  

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