Adar1-dependent editing regulates human β cell transcriptome diversity during inflammation

HIGHLIGHTS

• who: Florian Szymczak from the Complutense University, Spain have published the research work: ADAR1-dependent editing regulates human u03b2u00a0cell transcriptome diversity during inflammation, in the Journal: (JOURNAL)
• what: The authors show that both IFNa and IFNg/IL1b stimulation promote ADAR1 expression and increase the A-to-I RNA editing of Alu-Containing mRNAs in EndoC-bH1 cells as well as in primary human islets. The authors demonstrate that ADAR1 overexpression inhibits type I interferon response signaling, while ADAR1 silencing potentiates IFNa effects. The authors demonstrate herein that inflammatory-mediated changes characteristic of early and late . . .
  

   

  

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