HIGHLIGHTS
SUMMARY
The authors explored the therapeutic potential of FVa delivered by AAV vectors in hemophilia mice with or without pre-existing FVIII inhibitors. Frontiers in Medicine For fibrinolysis analysis, ROTEM was employed, which can provide global information on the dynamics of clot development, stabilization, and dissolution, which reflect in_vivo hemostasis. "hFVa" was chosen as the candidate for AAV vector package and further in_vivo study. At the end of experiments, all mice were used for tail vein transection to evaluate the hemostatic improvement in AAV8/FVa treatment in_vivo. (3) It is also worth noting that the . . .
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