Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the ahr/stat3/il-6 signaling

HIGHLIGHTS

  • who: Teng Huang from the the Center for Huazhong University have published the article: Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
  • what: Unfortunately, most of the studies were focused on the metabolism of carbohydrate and lipid within the adipocytes, while alterations in amino_acid metabolism in adipocytes and the related pathogenesis are less investigated.
  • how: 6 To further confirm the above results a rescue experiment was conducted in adipocytes. To verify the effect of Kyn-induced IL-6 . . .

     

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