Adipose-derived exosomes block muscular stem cell proliferation in aged mouse by delivering mirna let-7d-3p that targets transcription factor hmga2

HIGHLIGHTS

• who: Maki Itokazu from the Ethics statement The Institutional Review Board of the Kindai University Faculty of Medicine approved the human tissue procurement protocolThe tissue specimens used in this study were collected at the margin of devitalized and healthy-appearing tissue that would otherwise be discarded as surgical waste. Tissue samples were retrieved from young patients (, males and , females, mean age=31., years) and aged patients (, males and , females, mean age=77.5) that received total hip arthroplasty and anterior cruciate ligament reconstruction at the Kindai University Hospital. All animal handling, care, operation, and sacrifice procedures were . . .
  

   

  

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