Adjustment for index event bias in genome-wide association studies of subsequent events

HIGHLIGHTS

• who: Frank Dudbridge from the University of of Clinical Medicine, Cambridge , SP, UK have published the paper: Adjustment for index event bias in genome-wide association studies of subsequent events, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors propose an adjustment for index event bias in GWAS of subsequent events. The authors explore this assumption in the following simulations and return to this point in the Discussion. Under strong negative genetic correlation, the approach has slightly increased type-1 error compared with the unadjusted analysis. The authors focus only on the effect of . . .
  

   

  

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