Adolescent stress accelerates postpartum novelty recognition impairment in 5xfad mice

HIGHLIGHTS

• What: This study investigated the effects of late adolescent social isolation combined with pregnancy and delivery on novelty recognition deficits in 5xFAD female mice. The authors focused the study solely on 5xFAD mice, making it challenging to conclude the effects of 5xFAD mutations. Despite these limitations, the authors believe the study provides valuable data indicating the important role of adolescent stress in accelerating AD pathology in the context of pregnancy and the postpartum period. While the study provides novel insights into the intricate relationship among stress, hormonal factors, and cognitive deficits in the context of AD, particularly . . .
  

   

  

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