Adoptive immunotherapy with engineered inkt cells to target cancer cells and the suppressive microenvironment

HIGHLIGHTS

  • who: Gloria Delfanti and collaborators from the a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy, Vita-Salute San Raffaele University, Milan, Italy have published the research work: Adoptive Immunotherapy With Engineered iNKT Cells to Target Cancer Cells and the Suppressive Microenvironment, in the Journal: (JOURNAL)

SUMMARY

    One of the iNKT_cell functional hallmarks is their avid autoreactivity upon recognition of stress-associated cell endogenous lipids. iNKT_cells undergo a distinct developmental pathway compared to T_cells, leading to the acquisition of innate effector functions already in the thymus. Thymic iNKT_cells indeed express markers usually . . .

     

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