Advanced fabrication of mirna-based electrochemical nanobiosensor for diagnosis of breast cancer

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SUMMARY

    Within the scope of the study, the binding of miR-155 to the synthesized Cys-graft-p (HEMA) nanopolymer was achieved with the disulfide bond (S-S) formed between the thiol group originating from the cysteine amino_acid in the nanopolymer and the thiol group in the conjugate probe of the thylated miR-155. After SEM analysis in nanopolymers, % S (Sulfur) analysis was performed due to the grafting of the cysteine amino_acid. While preparing Cys-graft-p(HEMA) nanopolymers used in the developed nanobiosensor system, p(HEMA) nanopolymers were synthesized by mini-emulsion polymerization method . . .

     

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