HIGHLIGHTS
- who: ProTide and colleagues from the Shanghai University of Traditional Chinese Medicine, China have published the research work: Advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies, in the Journal: (JOURNAL)
- what: Whereas, the primary endpoint of this study was not met, and no efficacy signal was identified for CP-4126 in treating pancreatic adenocarcinoma with progressive metastatic disease (Li et_al, 2014).
SUMMARY
To induce cytotoxicity, these compounds act as antimetabolites, competing with physiological nucleosides, and interacting with a multitude of intracellular targets (Galmarini et_al, 2001; Galmarini et_al . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.