HIGHLIGHTS
- who: March and collaborators from the University of Illinois at UrbanaChampaign, United have published the research: Advances and challenges in CRISPR-based real-time imaging of dynamic genome organization, in the Journal: (JOURNAL)
- future: Future studies are required to understand if different chromosome conformations correlate to different transcription profiles. Multiple labeled loci (>2 loci) are required to measure the dynamic folding of larger chromosomal domains in sufficient detail which emphasizes the importance of robust live-cell multicolor imaging or chromosome paint techniques for future studies.
SUMMARY
Chromatin is hierarchically folded to . . .
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