Advances in the development of small molecule antivirals against equine encephalitic viruses

HIGHLIGHTS

  • who: Tyler J. Ogorek and Jennifer E. Golden from the Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA have published the research work: Advances in the Development of Small Molecule Antivirals against Equine Encephalitic Viruses, in the Journal: Viruses 2023, 413 of /2023/
  • what: In a follow-up AlphaScreen performed by this research group, compound was inactive when deployed against a capsid protein-mutated strain of VEEV several structurally related pyrrole and that tetrahydrobenTC83 which1,4-diazepines was incapable ofbearing engagingring-fused IMPu03b1, providing evidence 1111684 disrupts zothiophene moieties were identified . In this . . .

     

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