HIGHLIGHTS
SUMMARY
Mechanisms in the Pathophysiology of APS Evidence of the thrombogenic activity of aPLs has been provided by both in_vitro and in_vivo studies; however, despite the presence of aPLs in the circulation, thrombotic manifestation is not always observed in the patients. At the end, the heterogeneity of the mechanisms underlying APS may be related to the different signal_transduction pathways triggered by aPLs. As a result, the structural properties of microdo‐ mains can promote compartmentalization of plasma_membrane proteins that have a higher affinity for the liquid‐ordered phase, while they will exclude proteins that have higher . . .
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