Aft1 nuclear localization and transcriptional response to iron starvation rely upon torc2/ypk1 signaling andsphingolipid biosynthesis

HIGHLIGHTS

• who: Sandra Montellu00e0-Manuel et al. from the (IRBLleida), University of, Spain have published the research: Aft1 Nuclear Localization and Transcriptional Response to Iron Starvation Rely upon TORC2/Ypk1 Signaling andSphingolipid Biosynthesis, in the Journal: (JOURNAL)
• what: The authors demonstrate that the AGC kinase as well as its upstream regulator TOR Complex 2 (TORC2) are required for proper following iron deprivation. Remarkably the authors demonstrate that and a robust transcriptional response to iron starvation also require of sphingolipids including complex sphingolipids such as inositol phosphorylceramide (IPC) and upstream precursors e_g long-chain bases (LCBs) and . . .
  

   

  

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