Age-dependent changes in circulating tfh cells influence development of functional malaria antibodies in children

HIGHLIGHTS

• who: Jo-Anne Chan from the InstitutMonash University, Melbourne, VIC, Australia have published the research work: Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors focused the studies on CXCR5+ PD1+ cells as this CD4 T_cells subset produces the largest ammounts of Tfh cytokine IL21, and most strongly resembles germinal centre Tfh cells at the transcriptional level10. For the present study, samples were collected between January and April 2013 during a period of high malaria burden, with an average . . .
  

   

  

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