Aggregation of alpha-synuclein in enteric neurons does not impact function in vitro

HIGHLIGHTS

• who: Adam J. Bindas from the DepartmentNortheastern University have published the paper: Aggregation of alpha-synuclein in enteric neurons does not impact function in vitro, in the Journal: Scientific Reports Scientific Reports
• what: The authors assess uptake and retention of fluorescently tagged PFFs by rat enteric neurons under different dosages and co-administer key luminal contents (butyrate and LPS) as modulators using live microscopy over a 21 days, after which the cultures are immunostained and analyzed for aggregated a-Syn average fluorescent intensity. The authors assess morphological growth cone, electrophysiological firing, and substance P levels . . .
  

   

  

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