Aggregative trans-eqtl analysis detects trait-specific target gene sets in whole blood

HIGHLIGHTS

• who: Diptavo Dutta from the Hopkins University have published the paper: Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors propose a summary-statistics based method using sparse canonical correlation analysis (sCCA)22-27 framework, termed Aggregative tRans assoCiation to detect pHenotype specIfic gEne-sets (ARCHIE), which identifies sets of distal genes whose expression levels are trans-associated to (or regulated by) groups of GWAS SNPs associated to a trait. The authors propose a resampling-based method to assess the statistical . . .
  

   

  

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