HIGHLIGHTS
- who: Xuhui Yan from the (UNIVERSITY) have published the article: AI-empowered integrative structural characterization of m6A methyltransferase complex, in the Journal: (JOURNAL) of 20/07/2022
SUMMARY
Two WTAP171-237 molecules (designated WTAPA and WTAPB) formed an asymmetric homodimer (the "flag pole") while VIRMA381-1292 that contains 17 armadillo-like (ARML) repeats (designated ARML 1-17) formed a twisted α-solenoid-like superhelix (the "flag"). Hydrophobic interactions were found between WTAPA and WTAPB residues 180-236 through the side-chain interactions of WTAPA-WTAPB residue pairs L183A-I180B (L183 from WTAPA and I180 . . .
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