HIGHLIGHTS
- who: Yanfei Qi from the Jiangsu University, China have published the article: Aire and Fezf2, two regulators in medullary thymic epithelial cells, control autoimmune diseases by regulating TSAs: Partner or complementer?, in the Journal: (JOURNAL)
SUMMARY
In all vertebrates, T lymphocytes develop in the thymus, and T-cell receptor (TCR) diversification is a random process that is generated through somatic DNA rearrangement to provide sufficient immune coverage. Autoreactive T_cells are eliminated via negative selection in the thymus, a process that contributes to the establishment of central tolerance. Cortical TECs (cTECs) that reside in . . .
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