HIGHLIGHTS
- who: Xiaofan Tu from the University of Newcastle, Newcastle, NSW, Australia have published the research: Airway and parenchyma transcriptomics in a house dust mite model of experimental asthma, in the Journal: (JOURNAL)
- what: This study shows that SPI1 is important in HDM-induced experimental asthma and that its pharmacological inhibition reduces HDM-induced collagen deposition and hyperresponsiveness. Using pharmacological inhibitors of SPI1, DB1976 and DB2313, the authors show that treatment with these compounds has differential effects at different doses on airway-associated mucus secreting cell numbers and small airway collagen deposition, with no protective effects . . .
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