Airway epithelial cell junctions as targets for pathogens and antimicrobial therapy

HIGHLIGHTS

  • who: Nannan Gao and Fariba Rezaee from the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA have published the research work: Airway Epithelial Cell Junctions as Targets for Pathogens and Antimicrobial Therapy, in the Journal: Pharmaceutics 2022, 14, 2619. of /2022/
  • what: This study showed that the u03b1-toxin-ADAM10 complex was assembled in cholesterol/sphingolipid-rich caveolar rafts on the membrane, which likely provided access to deactivate caveolae-associated proteins FAK and Src.
  • how: This review discusses the pathophysiologic mechanisms by which several microorganisms (bacteria and . . .

     

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