HIGHLIGHTS
- who: Endocrinology et al. from the Centre for Diabetes, and Metabolism, NIHR Biomedical Research Centre, University of, Churchill Hospital, UK have published the research work: AKR1D1 knockout mice develop a sex-dependent metabolic phenotype, in the Journal: (JOURNAL)
- what: This study shows that AKR1D1 controls bile acid homeostasis in vivo and that altering its activity can affect insulin tolerance and lipid homeostasis in a sex-dependent manner.
SUMMARY
The authors have recently shown that manipulating AKR1D1 activity in_vitro alters glucocorticoid and bile acid action with effects on insulin signalling, as well . . .
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