Akt mutant allele-specific activation dictates pharmacologic sensitivities

HIGHLIGHTS

• who: Tripti Shrestha Bhattarai from the Kravis Center for have published the Article: AKT mutant allele-specific activation dictates pharmacologic sensitivities, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The study aimed to accrue 12 patients in each cohort.
• how: This result is consistent with the more potent induction of PI3K pathway activation by the indels. Based on the data indicating that AKT indel mutant cells were resistant to allosteric inhibition the authors chose to test the efficacy of capivasertib in this trial. Upon sequencing a biopsy obtained from the postprogression tumor the . . .
  

   

  

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