Alcohol inhibits the metabolism of dimethyl fumarate to the active metabolite responsible for decreasing relapse frequency in the treatment of multiple sclerosis

HIGHLIGHTS

• who: Bing Yang and collaborators from the Editor:, Central University of have published the Article: Alcohol inhibits the metabolism of dimethyl fumarate to the active metabolite responsible for decreasing relapse frequency in the treatment of multiple sclerosis, in the Journal: PLOS ONE of 10/Nov/2022
• what: This study of the interaction between alcohol and DMF in a mouse model identifies a drastic change in the disposition of DMF and its active MMF metabolite resulting in a significant decrease in MMF exposure in the central nervous system.
• how: The authors conducted a series . . .
  

   

  

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