Alkyl-resorcinol derivatives as inhibitors of gdp-mannose pyrophosphorylase with antileishmanial activities

HIGHLIGHTS

• who: Hu00e9lu00e8ne Levaique et al. from the CNRS, Institut de Chimie des Substances Naturelles, Universitu00e9 Paris-Saclay, UPR, Gif-sur-Yvette, Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia have published the Article: Alkyl-Resorcinol Derivatives as Inhibitors of GDP-Mannose Pyrophosphorylase with Antileishmanial Activities, in the Journal: Molecules 2021, 26, 1551. of /2021/

SUMMARY

A knockout in L mexicana demonstrated that GDP-MP is essential for amastigote survival both in_vitro and in_vivo. To increase the diversity of leishmanial GDP-MP inhibitors, the authors screened a library of 5000 . . .

 



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