All-optical observation on activity-dependent nanoscale dynamics of myelinated axons

HIGHLIGHTS

• who: Myunghwan Choi from the Sungkyunkwan University, Department of Biomedical Engineering, Suwon, Republic of Korea have published the paper: All-optical observation on activity-dependent nanoscale dynamics of myelinated axons, in the Journal: (JOURNAL) of 01/02/2023
• what: The authors aim to observe activity-dependent nanostructural dynamics of myelinated axons in a living brain tissue. By combining the nanoscale readout based on spectral interferometry (SpeRe) and optogenetic manipulation of neural excitation, the authors report the first experimental evidence that myelinated axons exhibit activity-dependent subnanometer-scale morphological dynamics of ~0.5 nm.
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