Allele-specific silencing of the gain-of-function mutation in huntington’s disease using crispr-cas9 jun wan shin , eun pyo hong , seri s. park , doo eun choi , ihn sik seong , madelynn n

HIGHLIGHTS

• who: jml from the Center for Genomic, Boston, MA, USA have published the article: Allele-specific silencing of the gain-of-function mutation in Huntington's disease using CRISPR-Cas9 Jun Wan Shin , Eun Pyo Hong , Seri S. Park , Doo Eun Choi , Ihn Sik Seong , Madelynn N, in the Journal: (JOURNAL)
• what: The authors reason that identification of DNA variants that are compatible with diverse engineered Cas9 variants with different PAM specificities will significantly increase the applicability of PAS-based mutant-specific NMD-CRISPR-Cas strategies for HD.
• how: Aiming at identifying exonic . . .
  

   

  

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