Allosteric activation of preformed egf receptor dimers by a single ligand binding event

HIGHLIGHTS

• who: Endang R. Purba from the Institut National de la Santu00e9 et de la Recherche Mu00e9dicale (INSERM), France Toronto Metropolitan University have published the article: Allosteric activation of preformed EGF receptor dimers by a single ligand binding event, in the Journal: (JOURNAL)
• what: The authors analyzed the structures of full-length EGFR in the absence and presence of a bound ligand. This study shows that, unlike previously observed , detergent-solubilized full-length EGFR adopts a dimeric form before and after the receptor activation in_vitro, when analyzed by gel_filtration chromatography and cryo-ET.
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