Allosteric inhibition of c-abl to induce unfolded protein response and cell death in multiple myeloma

HIGHLIGHTS

• who: Hideki Kosako and collaborators from the Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan have published the research work: Allosteric Inhibition of c-Abl to Induce Unfolded Protein Response and Cell Death in Multiple Myeloma, in the Journal: (JOURNAL) of 28/09/2021
• what: This motivated the authors to investigate the effect(s) of the pharmacological modulation of c-Abl on MM. This study aimed to clarify whether and how allosteric c-Abl inhibitors exhibited anti-myeloma effect(s) in the context of UPR signaling. Subsequently, the authors focused on UPR (enrichment score . . .
  

   

  

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