Allosteric modulation of the calcium-sensing receptor rectifies signaling abnormalities associated with g-protein α-11 mutations causing hypercalcemic and hypocalcemic disorders*

HIGHLIGHTS

• who: Valerie N. Babinsky from the (UNIVERSITY) have published the research: Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein u03b1-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders*, in the Journal: (JOURNAL) of May/13,/2016
• what: The studies demonstrate that cinacalcet and NPS-2143, which are allosteric CaSR activators and inactivators, respectively, can successfully rectify the loss-of-function associated with FHH2causing Gu242311 mutations and the gain-of-function associated with Gu242311 mutations that lead to ADH2 or uveal melanomas . The studies have revealed that germline gain-offunction Gu242311 . . .
  

   

  

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