Allosteric regulation in stat3 interdomains is mediated by a rigid core: sh2 domain regulation by ccd in d170a variant

HIGHLIGHTS

• who: Tingting Zhao et al. from the Department of Chemistry, Southern Methodist University, Dallas, Texas, United States of America have published the paper: Allosteric regulation in STAT3 interdomains is mediated by a rigid core: SH2 domain regulation by CCD in D170A variant, in the Journal: (JOURNAL) of December/21,/2022
• what: The authors investigate structural and dynamic features of STAT3 and compare the wild type to the reduced function variant D170A to delineate mechanistic differences and propose allosteric pathways. The authors show that CCD regulates SH2 conformation via a rigid backbone. Specifically, the authors investigate . . .
  

   

  

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