Alpha ketoglutarate exerts in vitro anti-osteosarcoma effects through inhibition of cell proliferation, induction of apoptosis via the jnk and caspase 9-dependent mechanism, and suppression of tgf- and vegf production and metastatic potential of cells

HIGHLIGHTS

• who: Katarzyna Kaławaj et al. from the Department of Virology and Immunology, Maria Curie-Sklodowska University, Akademicka , have published the article: Alpha Ketoglutarate Exerts In Vitro Anti-Osteosarcoma Effects through Inhibition of Cell Proliferation, Induction of Apoptosis via the JNK and Caspase 9-Dependent Mechanism, and Suppression of TGF- and VEGF Production and Metastatic Potential of Cells, in the Journal: (JOURNAL)
• what: This study was intended to check whether supplementation of Saos-2 and HOS osteosarcoma cell lines (harboring a TP53 mutation) with exogenous AKG exerted an anti-cancer effect. Since AKG caused the . . .
  

   

  

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