HIGHLIGHTS
SUMMARY
The excess of reactive oxygen species (ROS) production related to endogenous antioxidant defenses is a primary mechanism contributing to reduced NO bioavailability, inducing vascular dysfunction with age. Control rats received saline injection. When the rat vocalized or withdrew its paw to respond to uniformly increasing pressure, the sinking threshold of the animal was recorded in grams. Five measurements of the mechanical nociceptive threshold were taken and averaged for each rat. As expected, all rats gained weight with aging, although BN rats were significantly lighter than Wistar rats regardless of age. In the BN strain . . .
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