Alpha1-adrenergic receptor blockade in the ventral tegmental area attenuates acquisition of cocaine-induced pavlovian associative learning

HIGHLIGHTS

• who: Wojciech B. Solecki from the University of Crete, Greece have published the Article: Alpha1-adrenergic receptor blockade in the ventral tegmental area attenuates acquisition of cocaine-induced Pavlovian associative learning, in the Journal: (JOURNAL)
• what: The authors propose that facilitation of phasic DA release in this circuit is a potential mechanism through which NA promotes salience encoding in the VTA. The authors propose that a salient stimulus such as cocaine, upregulates NAergic activity in the VTA, likely via α1 -ARs expressed on DA neurons.
• how: The results indicated that 20 mg/kg . . .
  

   

  

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