HIGHLIGHTS
SUMMARY
The authors identified that in APC-wt/MSS colon cancer, the expressions of PD-1, PD-L1, CTLA4, and CYT (GZMA and PRF1) were increased. Similarly, the significant pathways for DEGs were mainly enriched in the immune_response, extracellular matrix, and cell adhesion which involved in immune_response. Specimens from 42 colon cancer patients, including 22 APC-mt/MSS and 20 APC-wt/MSS, were immunohistochemically evaluated for expression of CD8 and PD-L1. Based on the results, the authors found that more colon cancers of APC-wt/MSS are classified by TMIT I. And APC . . .
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