HIGHLIGHTS
- who: Anna C. Pfalzer from the DepartmentVanderbilt University have published the article: Alterations in metal homeostasis occur prior to canonical markers in Huntington disease, in the Journal: Scientific Reports Scientific Reports
- what: Although the authors demonstrate clear elevations in CSF metals prior to elevations in canonical markers of disease, the cause of these extracellular changes and their intracellular consequences remain unclear. The observed elevations in CSF Cu early in disease may not recapitulate intracellular levels, in fact, the authors propose that in HD, Cu is sequestered by mutant HTT and thus creates conditions of intracellular . . .
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