HIGHLIGHTS
- who: October et al. from the University of Milan, Italy have published the paper: Altered contractility in mutation-speci c hypertrophic cardiomyopathy: A mechano-energetic in silico study with pharmacological insights, in the Journal: (JOURNAL)
- what: The authors investigate the pathophysiology of HCM R403Q myosin mutation using a computational metabolite-sensitive model of hiPSC-CMs electromechanics developed based on ordinary differential equations (ODEs). The authors have taken this metabolite-sensitive CE model proposed by Tran et_al , and modified it to incorporate active contraction mechanisms integrated with the Paci2020 model of hiPSC-CMs electrophysiology (Paci et_al . . .
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