Altered expression of tmem43 causes abnormal cardiac structure and function in zebrafish

HIGHLIGHTS

• who: Miriam Zink et al. from the Comprehensive Heart Failure Center, Department of Internal Medicine I, University Hospital Wu00fcrzburg, Wu00fcrzburg, Germany have published the paper: Altered Expression of TMEM43 Causes Abnormal Cardiac Structure and Function in Zebrafish, in the Journal: (JOURNAL) of 27/07/2017
• what: The authors report, for the first time, the generation and characterization of transgenic zebrafish lines carrying either different ACM-associated TMEM43 variants (c.332C>T, p.P111L; c.1073C>T, p.S358L) or tmem43 knock-out mutations. The authors demonstrate that TMEM43 variants lead to ultrastructural remodeling and transcriptomic . . .
  

   

  

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