Altered macronutrient composition and genetics influence the complex transcriptional network associated with adiposity in the collaborative cross

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SUMMARY

    Although genetics have a stronger effect on susceptibility to developing obesity than diet alone, the role of diet as an environmental factor that influences gene_expression is still important, since changes in dietary patterns can help mitigate the degree of obesity that develops by altering gene_expression levels. To assess which genes` expression levels are affected by diet, differential gene_expression analysis was performed using the R package limma (linear models for microarray) on liver gene_expression data. Differences in diet macronutrient composition had mild effects on broad sense heritability ­(H2) estimates for gene_expression levels To quantify the . . .

     

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