HIGHLIGHTS
- who: Faye McLeod and collaborators from the (UNIVERSITY) have published the research work: Altered synaptic connectivity in an in vitro human model of STXBP1 encephalopathy, in the Journal: (JOURNAL)
- what: Synapse maturation in human cortical slice cultures Given the relatively higher expression of STXBP1 in the subplate at 16-17 pcw and higher density of pre-synaptic terminals in the upper subplate (Fig 1A), the authors focused on this age and location for subsequent analysis of how the organotypic cultures continue to develop in_vitro. In these initial proof-of-principle studies, using a simple shRNA . . .
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