HIGHLIGHTS
- who: Ilaria Passacantilli from the DepartmentUniversity of of Neuroembryology, Fondazione Santa Lucia IRCCS, Rome, Italy have published the research: Alternative polyadenylation of ZEB1 promotes its translation during genotoxic stress in pancreatic cancer cells, in the Journal: (JOURNAL)
- future: These observations suggest that further mechanistic studies will be required to dissect the exact mechanism(s) involved in ZEB1 APA regulation during genotoxic stress.
SUMMARY
This shorter ZEB1 transcript variant was more efficiently associated with polysomes than longer ZEB1 transcripts in cells exposed to the drug. The findings highlight a novel mechanism involved . . .
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