HIGHLIGHTS
- who: Kevin Baß et al. from the University of California, Los Angeles, United have published the article: Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation, in the Journal: (JOURNAL)
- what: Since TGFB1 was both predicted as a signaling pathway of transcriptional regulation , the authors focused further analysis on this ligand. This analysis showed a tendency towards increased LAP TGF-b1 levels in COPD . To define potential upstream regulators for changes observed in COPD, the authors focused on those macrophage states with a minimum of 30 DE genes . . .
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