HIGHLIGHTS
SUMMARY
According to the literature, compared with young and middle-aged people, older people have an increased level of both proinflammatory cytokines such as IL-1, IL-2, IL-6, IL-8, IL-12, IL-15, IL-17, IL-18, IL-22, IL-23, TNF-α, and IFN-γ, and anti-inflammatory ones like IL-1Ra, IL-4, IL-10, IL-37, and TGF-β1. As a result, the number and duration of functioning of SASP-secreting cells increases, ultimately leading to the aging of tissues and the body altogether, and also increases the risk of developing . . .
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