HIGHLIGHTS
- who: Miriam Butler from the (UNIVERSITY) have published the research: Amino Acid Depletion Therapies: Starving Cancer Cells to Death, in the Journal: (JOURNAL)
SUMMARY
Advances in chemotherapy and supportive care, but also the introduction of targeted- and immune-therapies, have led to increased survival of cancer patients over the past decades. While the cancer cell-specific diversion of carbohydrate intermediates from oxidative_phosphorylation towards several anabolic pathways, known as the Warburg effect, has been long recognized, attention for amino_acid dependencies in cancer cells came decades later. The authors discuss the biology behind the most . . .
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