Amino acid substitutions in human growth hormone affect secondary structure and receptor binding

HIGHLIGHTS

• who: Andrei Rajkovic and collaborators from the Department of Cell and Molecular Biology, Department of have published the Article: Amino acid substitutions in human growth hormone affect secondary structure and receptor binding, in the Journal: PLOS ONE of February/22,/2023
• what: The authors show that E174A increases affinity of hGH against hGHR because the off-rate is slowed down more than the on-rate. The authors confirm the earlier reported increase in affinity of E174A, but now clarify that it is due to a decrease in koff which more than counters a decrease in . . .
  

   

  

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